| Autor: |
R. Samsonov, N. A. Germanov, S. V. Mochalov, Sergey Pulnev, Margarita L. Tyndyk, A. Malek, Viktor Anisimov, Irina G. Popovich, S. Golyadin |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Problems in oncology. 65:760-765 |
| ISSN: |
0507-3758 |
| DOI: |
10.37469/0507-3758-2019-65-5-760-765 |
| Popis: |
The paper presents the results of the research on the antitumor activity of a new drug - atomic clusters of silver (ACS), the colloidal solution of nanostructured silver bisilicate Ag6Si2O7 with particles size of 1-2 nm in deionized water. In vitro studies to evaluate the effect of various ACS concentrations in human tumor cells cultures (breast cancer, colon carcinoma and prostate cancer) were conducted. The highest antitumor activity of ACS was observed in dilutions from 2.7 mg/l to 5.1 mg/l, resulting in the death of tumor cells in all studied cell cultures. In vivo experiments on transplanted Ehrlich carcinoma model in mice consuming 0.75 mg/kg ACS with drinking water revealed significant inhibition of tumor growth since the 14th day of experiment (maximally by 52% on the 28th day, p < 0.05) in comparison with control. Subcutaneous injections of 2.5 mg/kg ACS inhibited Ehrlich's tumor growth on the 7th and 10th days of the experiment (p < 0.05) as compared to control. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
