Prognostic value of the level of cortisol and ACTH in the blood of patients with Itsenko-Cushing's disease during surgical treatment with corticotropin

Autor:	E. I. Marova, S. D. Arapova, Yu. K. Trunin, G. D. Nersesyan, S. Yu. Kasumova, Boris A. Kadashev, N. P. Goncharov, G S Kolesnikova
Rok vydání:	1998
Předmět:	medicine.medical_specialty business.industry Endocrinology Diabetes and Metabolism Internal medicine Medicine Cushing's disease Surgical treatment business medicine.disease Gastroenterology Value (mathematics)
Zdroj:	Problems of Endocrinology. 44:26-29
ISSN:	2308-1430 0375-9660
DOI:	10.14341/probl11665
Popis:	Adenomectomy was carried out in 41 patients with Icenko-Cushing’s disease. Before surgery, computer-aided tomography showed pituitary adenomas in all the patients. The patients were divided into 2 groups. Group 1 consisted of 31 patients in whom the disease was diagnosed for the first time and group 2 of 10 patients previously treated by other methods (proton ther- ару and unilateral adrenalectomy) without effect. Pituitary adenomas were removed in all patients. Histological study showed hormone-active pituitary adenomas in all cases. The levels of hydrocortisone and ACTH in the plasma and daily urine were increased in both groups before the operation. Ten-twenty days after surgery, the levels of hydrocortisone and ACTH in group 1 were significantly lower than in group 2. We consider that the lower are the levels of these hormones early after surgery, the lower is the probability of a relapse. Postoperative hypocorticalism (10-20 days postoperation) is a good prognostic sign indicating radical removal of pituitary adenoma. Adenomectomy is indicated for patients with Icenko-Cushing’s disease as primary method of treatment.
Databáze:	OpenAIRE
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