Anaphylaxis during the first course of high-dose methotrexate: a case report and literature review
| Autor: | Michele Vietri, A. Tondo, Alessandro Mugelli, Alfredo Vannacci, Silvia Benemei, Francesco Lapi, Alessandra Pugi, Anna Maria Calvani |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
musculoskeletal diseases
Pharmacology Osteoblastic osteosarcoma medicine.medical_specialty business.industry medicine.disease High dose methotrexate Dermatology Surgery Paediatric cancer Pharmacovigilance medicine Pharmacology (medical) Methotrexate business Adverse effect Anaphylaxis Adverse drug reaction medicine.drug |
| Zdroj: | Journal of Clinical Pharmacy and Therapeutics. 37:245-248 |
| ISSN: | 0269-4727 |
| DOI: | 10.1111/j.1365-2710.2011.01275.x |
| Popis: | Summary What is known and Objective: Methotrexate (MTX) is widely used in the management of paediatric cancer with a generally favourable benefit/risk profile. We report an unusual adverse drug reaction with the first course of high-dose MTX in a paediatric patient and review the literature for similar cases. Case summary: An 11-year-old boy with small-cell osteoblastic osteosarcoma in the lower limb experienced a case of life-threatening anaphylaxis during the first course of high-dose MTX. The adverse event occurred during the first course, likely due to an immune-mediated mechanism. We postulate that prior antineoplastic treatment might have contributed to the immune response to MTX. What is new and Conclusion: Given that this reaction has rarely been reported, we discuss the present case with a review of other similar cases. Further studies are needed to substantiate this ‘signal alarm’ for serious MTX-related hypersensitivity reactions. |
| Databáze: | OpenAIRE |
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