Synthesis and antinociceptive activity of 4,4′-bis(1-substituted-semicarbazidyl)diphenylmethane and 4,4′-bis(5-substituted-2,4-dihydro-3-oxo-3H-1,2,4-triazol-4-yl)diphenylmethane derivatives

Autor:	Mariusz Maciejewski, Anna Pachuta-Stec, Monika Pitucha, Anna Chodkowska, Ewa Jagiełło-Wójtowicz
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Semicarbazide chemistry.chemical_compound chemistry Carboxylic acid Organic chemistry Diphenylmethane General Chemistry Cns activity Diphenylmethane derivatives
Zdroj:	Monatshefte für Chemie - Chemical Monthly. 141:199-203
ISSN:	1434-4475 0026-9247
DOI:	10.1007/s00706-009-0242-3
Popis:	In the reaction of 4,4′-diphenylmethane diisocyanate with carboxylic acid hydrazides, 4,4′-bis(1-substituted-semicarbazidyl)diphenylmethane derivatives were obtained. Depending on their chemical nature, cyclization of these compounds in alkaline medium led to the formation of two groups of compounds: bis(2,4-dihydro-3H-1,2,4-triazol-3-one) derivatives or carboxylic acids. The pharmacological effects of the selected compounds on the central nervous system in mice were investigated. Strong antinociceptive properties of some derivatives, at a wide range of doses, were observed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::97d2d8373207808cfe0c9f908fb7ece7 https://doi.org/10.1007/s00706-009-0242-3 Zobrazit plný text záznamu Full text from SpringerLink