Linkage study of early-onset obesity to leptin receptor gene in Italian children

Autor:	Maria Teresa Carbone, Claudia Calabro, Laura Perrone, Rosario Di Toro, P Forabosco, Marcella Devoto, Emanuele Miraglia del Giudice
Rok vydání:	2000
Předmět:	Linkage (software) Genetics medicine.medical_specialty Nutrition and Dietetics Endocrinology Diabetes and Metabolism Haplotype Biology Quantitative trait locus Identity by descent Genetic determinism Endocrinology Genetic linkage Internal medicine medicine Microsatellite Allele
Zdroj:	Nutrition Research. 20:1059-1063
ISSN:	0271-5317
DOI:	10.1016/s0271-5317(00)00193-7
Popis:	Analyses of twins as well as adopted children have shown that obesity has a considerable genetic component. An identical by descent (IBD) study in obese patients with very early onset of the disease has been performed in order to evaluate the linkage of the leptin receptor gene (OB-R) to obesity. Forty-eight couples of discordant (affected-unaffected) Italian sibs have been chosen. Two highly polymorphic microsatellites within introns 1 and 14 of OB-R have been scored. Analysis of the haplotypes did not show any evidence of linkage (p 0.076). Quantitative trait linkage analysis evaluated by regressing the difference of the BMI between the two sibs of a pair as a function of the estimated proportion of alleles shared failed to show any significative evidence for linkage.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::97c3c7512c8a6692e1fa0ae39e73e440 https://doi.org/10.1016/s0271-5317(00)00193-7 Zobrazit plný text záznamu Full Text from ScienceDirect