Microbiology of Burns Treated with Carbenicillin: Experimental and Clinical Observations

Autor:	Robert B. Lindberg, Basil A. Pruitt, P. William Curreri
Rok vydání:	1970
Předmět:	medicine.medical_specialty Experimental model medicine.drug_class business.industry Mortality rate Antibiotics Carbenicillin medicine.disease Sepsis Clinical trial Infectious Diseases medicine Immunology and Allergy Severe burn business Intensive care medicine Complex problems medicine.drug
Zdroj:	Journal of Infectious Diseases. 122:S34-S39
ISSN:	1537-6613 0022-1899
DOI:	10.1093/infdis/122.supplement_1.s34
Popis:	ginosa, the principal pathogen causing sepsis from the bum wound [2, 3]. This topical therapy has lowered markedly the death rate due to sepsis from the burn wound, but sepsis from the bum wound, pulmonary involvement, and other sites remains a significant problem in management of the burn. The experimental model of bum-wound sepsis, which made possible the evolution of an effective topical therapy, has been useful in the assessment of other drugs in the treatment of burns. Invasion of the burn wound by Pseudomonas in this model is lethal unless protective therapy intervenes, and the model has been used to assess the potential effectiveness of carbenicillin (Geopen?Pfizer Inc.) in suppressing invasive sepsis due to Pseudomonas. Clinical trials of the antibiotic followed, but the complex problems presented by sepsis in severe burns obscure the effect of a specific antibiotic agent, and the animal response becomes an essential part of this evaluation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::97c2248e2efed50514c84a35bd4ab288 https://doi.org/10.1093/infdis/122.supplement_1.s34 Zobrazit plný text záznamu