Pathophysiology of inhibitors to factor VIII in patients with haemophilia A
| Autor: | C. Artaud, Michel D. Kazatchkine, Sébastien Lacroix-Desmazes, Jagadeesh Bayry, B. Drayton, Srinivas V. Kaveri, Namita Misra |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities biology business.industry animal diseases T cell Haemophilia A Hematology General Medicine medicine.disease Haemophilia Pathophysiology medicine.anatomical_structure Immune system hemic and lymphatic diseases Immunology biology.protein Medicine In patient Major complication Antibody business Genetics (clinical) |
| Zdroj: | Haemophilia. 8:273-279 |
| ISSN: | 1351-8216 |
| DOI: | 10.1046/j.1365-2516.2002.00624.x |
| Popis: | The occurrence of factor VIII (FVIII) inhibitors is one of the major complications of the treatment of haemophilia A. We present this review as a description of the major players of the antiFVIII immune response, with particular emphasis on the nature and properties of the different antiFVIII antibodies, their mechanisms of action in inhibiting FVIII activity, their potential neutralization by anti-idiotypic antibodies, and the importance of the T cell in participating in the induction of FVIII inhibitors. We briefly conclude on the avenues that remain to be explored in order to establish efficient therapeutic approaches aimed at eliminating FVIII inhibitors in patients with haemophilia A. |
| Databáze: | OpenAIRE |
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