Synthesis of colchifoline from deacetylcolchiceine

Autor:	M. A. Iorio, Arnold Brossi, Marisa Molinari
Rok vydání:	1981
Předmět:	Deacetylcolchicine Chromatography Elution Diazomethane Organic Chemistry Ether General Chemistry Methylation Chloride Catalysis chemistry.chemical_compound Colchifoline chemistry Pyridine medicine Organic chemistry medicine.drug
Zdroj:	Canadian Journal of Chemistry. 59:283-284
ISSN:	1480-3291 0008-4042
DOI:	10.1139/v81-045
Popis:	Treatment of a mixture of deacetylcolchicine and deacetylisocolchicine, obtained by diazomethane methylation of deacetylcolchiceine, with trifluoroacetylglycolyl chloride in pyridine, afforded directly colchifoline and isocolchifoline. The two ether isomers could be separated by chromatography and the material eluted first proved to be identical with colchifoline isolated from commercial samples of colchicine.
Databáze:	OpenAIRE
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