Study of interactions of mononucleotides with 1,4-dihydropyridine vesicles using NMR and ITC techniques
| Autor: | E. E. Liepin'sh, Ruslan Muhamadejev, Marina Petrova, Aiva Plotniece, Gunars Duburs, Rufus Smits, Karlis Pajuste |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification endocrine system Vesicle Dihydropyridine Isothermal titration calorimetry General Chemistry Combinatorial chemistry Catalysis 03 medical and health sciences 030104 developmental biology chemistry Drug delivery Materials Chemistry medicine Proton NMR Nucleotide Titration Nucleoside medicine.drug |
| Zdroj: | New Journal of Chemistry. 42:6942-6948 |
| ISSN: | 1369-9261 1144-0546 |
| DOI: | 10.1039/c8nj00160j |
| Popis: | The use of 1,4-dihydropyridine (DHP) vesicles as drug delivery agents can improve the diffusion of nucleoside and nucleotide prodrugs through the cellular membrane without degradation. Different NMR studies: spin–lattice relaxation in the rotating frame (T1ρ), saturation transfer double difference (STDD), 1H NMR chemical shift titration, as well as isothermal titration calorimetry (ITC) experiments, showed that mononucleotides bind to 1,4-DHP vesicles. The influence of the structure of the mononucleotides as well as that of the derivatives of 1,4-DHP on the complexation parameters was studied. |
| Databáze: | OpenAIRE |
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