Die Synthese von 6,7-Dihydro-2H-pyrimido[6, 1-a]isochinolin-4(3H)-onen und analogen Verbindungen und deren Wirkung als Blutpättchenaggregationshemmer

Autor:	Yves Bounameaux, Reto Muggli, Rudolf E. Minder, Frank Kienzle
Rok vydání:	1986
Předmět:	Inorganic Chemistry Agonist Stereochemistry medicine.drug_class Chemistry Organic Chemistry Drug Discovery medicine Phosphodiesterase Biological activity Physical and Theoretical Chemistry Biochemistry Catalysis
Zdroj:	Helvetica Chimica Acta. 69:1671-1680
ISSN:	0018-019X
DOI:	10.1002/hlca.19860690722
Popis:	Synthesis of 6,7-Dihydro-2H-pyrimido[6,1-a]isoquinolin-4(3H)-ones and Analogous Compounds and their Activity as Blood-Platelet Inhibitors The synthesis of 6,7-dihydro-2H-pyrimido[6,1-a]isoquinolin-4(3H)-ones and of analogous compounds is described. These compounds are powerful phosphodiesterase inhibitors and, therefore, inhibit blood-platelet aggregation independent of the agonist. They exhibit, too, cardiac activities. However, there is evidence for selective action. A structure-activity relationship for platelet-aggregation inhibitors is discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::97acf9260adb35caae8ecadbbd854f2a https://doi.org/10.1002/hlca.19860690722 Zobrazit plný text záznamu Plný text