Hyperoxia enhances exercise performance in PAH and CTEPH: Randomized trial
| Autor: | Konrad E. Bloch, Séverine Müller-Mottet, Stephan Keusch, Silvia Ulrich, Michael Furian, Elisabeth D. Hasler, Stéphanie Saxer |
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| Rok vydání: | 2016 |
| Předmět: |
Hyperoxia
medicine.medical_specialty business.industry Oxygenation respiratory system medicine.disease Pulmonary hypertension respiratory tract diseases law.invention Randomized controlled trial law Internal medicine Heart rate Exercise performance medicine Cardiology Breathing Physical therapy Constant load medicine.symptom business circulatory and respiratory physiology |
| Zdroj: | 4.3 Pulmonary Circulation and Pulmonary Vascular Diseases. |
| DOI: | 10.1183/13993003.congress-2016.oa264 |
| Popis: | Pulmonary hypertension (PH) impairs oxygen delivery and exercise capacity. Aims: To investigate whether hyperoxia improves exercise performance in PAH or CTEPH. Methods: 22 stable PAH/CTEPH patients (8 women, 61±14y, mPAP 35±10mmHg) underwent 4 bicycle ergospirometries to exhaustion breathing FiO2 0.5 or air (FiO2 0.21) and using progressive or constant load (75%Wmax, FiO2 0.21) protocols, according to a randomized, cross-over design. Gas-exchange, SpO2, cerebral (CTO) and muscle (MTO) tissue oxygenation were monitored. Results: In progressive ramp tests under FiO2 0.5, Wmax, VO2max, SpO2, CTO and MTO exceed values during FiO2 0.21 at end-exercise, while VE/VCO2 and heart rate were reduced at isotime. In constant load tests with FiO2 0.5 endurance was increased by 210±223% vs. FiO2 0.21. Conclusions: In PAH/CTEPH, breathing FiO2 0.5 increases exercise performance by improving ventilatory efficiency and arterial oxygenation thereby enhancing oxygen availability in muscles and brain. Therefore, hyperoxia holds promise to improve efficacy of exercise training in PAH/CTEPH patients undergoing rehabilitation. |
| Databáze: | OpenAIRE |
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