Effect of topical corticosteroids on seasonal increases in epithelial eosinophils and mast cells in allergic rhinitis: a comparison of nasal brush and biopsy methods
| Autor: | Sigurdur Juliusson, B Balder, Stephen R. Durham, Mikila R. Jacobson, A. B. Kay, Olle Löwhagen |
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| Rok vydání: | 1999 |
| Předmět: |
Pathology
medicine.medical_specialty Allergy medicine.diagnostic_test business.industry medicine.medical_treatment Immunology Mucous membrane of nose respiratory system Eosinophil medicine.disease Fluticasone propionate medicine.anatomical_structure Nasal spray Biopsy otorhinolaryngologic diseases medicine Immunology and Allergy business Nose Fluticasone medicine.drug |
| Zdroj: | Clinical & Experimental Allergy. 29:1347-1355 |
| ISSN: | 0954-7894 |
| DOI: | 10.1046/j.1365-2222.1999.00608.x |
| Popis: | Background Nasal brushing and nasal biopsy are well-tolerated sampling techniques. Seasonal grass pollen-induced rhinitis is characterized by epithelial mast cell infiltration and seasonal increases in both epithelial and sub-mucosal eosinophils. Objective To compare the ability of the nasal brush and nasal biopsy techniques to detect natural seasonal increases in eosinophils and mast cells, and to assess the influence of topical corticosteroid. Methods Nasal brush samples and nasal biopsies were collected from 46 grass pollen-sensitive seasonal rhinitis patients before the grass pollen season and at the peak of the pollen season following 6 weeks' treatment with either fluticasone propionate aqueous nasal spray (200 μg, twice daily) or placebo nasal spray. Results Placebo patients showed seasonal increases in epithelial eosinophils both with nasal brushing (P |
| Databáze: | OpenAIRE |
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