ПІДБІР КІЛЬКІСНОГО СКЛАДУ КОМПОНЕНТІВ ПРИ РОЗРОБЦІ ВЕТЕРИНАРНОГО ПРЕПАРАТУ ДЛЯ ІНТРАЦИСТЕРНАЛЬНОГО ВВЕДЕННЯ

Autor: Zh. M. Polova, L. H. Almakayeva
Rok vydání: 2017
Předmět:
Zdroj: Фармацевтичний часопис.
ISSN: 2414-9926
2312-0967
DOI: 10.11603/2312-0967.2017.4.8336
Popis: The aim of the work. Development of qualitative composition and selection of the optimal ratio of the components of the combined veterinary drug for intramammary administration. Materials and M ethods. The study object was a series of preparations of the antimicrobial action "Argocide", which containing silver citrate, D-panthenol and L-arginine and is intended for the treatment and prevention of subclinical mastitis in cattle. Physico-chemical stability parameters of the preparation were studied at a temperature of 25 ± 2 ° C for long-term tests and at a temperature of 40 ± 2 ° C for accelerated tests; defined the following parameters in accordance with the requirements of the State Pharmacopoeia of Ukraine: the quantitative content of active substances, the appearance of the solution, transparency, pH. Results and D iscussion . As a result of the study of stability samples of the veterinary drug during storage with the following proportions of active substances: silver citrate – 0.01 g, L-arginine – 0.52 g, dexpanthenol – 0.50 g, it was found that, under long-term storage conditions, physical and chemical properties for 6 months did not change. The results of the accelerated tests revealed the instability of samples of the veterinary drug at earlier times, which may be a consequence of the destruction of silver citrate in the test samples. A research work was carried out to study the stability of the selected combination of active substances after changing its concentration in solution. The study was carried out by analyzing the results of observations of the stability of samples obtained by two methods. According to the first method, a veterinary dosage form was obtained, which is two sterile solutions – A and B, which are mixed before administration in a single syringe tube for intramammary use. The second method was different in that the solution was prepared immediately with the same concentrations of all components as in a mixed solution of A + B, with the selected ratio of active substances being the same. Conclusions. The optimal ratio of the components of a new combination intramammary preparation of antimicrobial action in the form of a solution in ampoules containing silver citrate 0.005 g, D-panthenol 0.260 g, and L-arginine 0.250 g for the treatment and prophylaxis of subclinical mastitis of cattle under the code name "Argocid", which is stable during storage for 12 months.
Databáze: OpenAIRE
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