| Autor: |
P. Helin, C. Garbarsch, M.E. Matthiessen, Ib Lorenzen |
| Rok vydání: |
1969 |
| Předmět: |
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| Zdroj: |
Journal of Atherosclerosis Research. 9:283-294 |
| ISSN: |
0368-1319 |
| DOI: |
10.1016/s0368-1319(69)80023-2 |
| Popis: |
Summary Male albino rabbits were exposed to short daily periods of systemic hypoxia for 2 weeks. Thirteen out of 16 rabbits showed gross arteriosclerotic changes, while no gross changes were found in 14 controls. The microscopic changes were primarily located to the media and consisted of calcified necrotic foci surrounded by amorphous, metachromatic intercellular substance. Metachromatic intercellular substance was also found in the form of “lakes” between the elastic membranes. A similar increase in the metachromatical intercellular substance was seen in the intima. The meta-chromasia indicated accumulation of acid mucopolysaccharides, which in the present study appeared to be primarily chondroitin-4-sulphate and/or chondroitin-6-sulphate and some dermatan sulphate and/or heparitin sulphate. A distinct calcification of the endothelial lining was observed. The changes probably reflect a damage of the aortic wall following systemic hypoxia and secondary non-specific processes of repair in the vascular connective tissue. The alterations have features in common with human arteriosclerosis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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