Scalable Synthesis of β-Lactamase Inhibitor QPX7728 by Sequential Nickel-Catalyzed Boron Insertion into a Benzofuran Substrate and Enantioselective Cyclopropanation of the Resulting Vinylboronate

Autor:	J.A. Hubertus Dielemans, Zuolin Zhu, Julia Schörghuber, Scott J. Hecker, André H.M. de Vries, Laurent Lefort, Angela Gonzalez-de-Castro, Serge H. Boyer, Stefan Steinhofer, Matthias Gnahn
Rok vydání:	2021
Předmět:	Cyclopropanation Organic Chemistry Enantioselective synthesis chemistry.chemical_element Substrate (chemistry) Combinatorial chemistry Catalysis Nickel chemistry.chemical_compound chemistry β lactamase inhibitor Physical and Theoretical Chemistry Benzofuran Boron
Zdroj:	Organic Process Research & Development. 26:925-935
ISSN:	1520-586X 1083-6160
DOI:	10.1021/acs.oprd.1c00285
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::97897342398f07f516e2c686bf15822b https://doi.org/10.1021/acs.oprd.1c00285 Zobrazit plný text záznamu