Practical Synthesis of Functionalized Chromeno[3,4-c]pyridine Derivatives via a CuCl2-Catalyzed Tandem Reaction of the Blaise Reaction Intermediates and 3-Cyanocoumarins

Autor:	Lei Zheng, Zhaohai Yang, Yangyang Fan, Jian-Jun Li, Zhiwei Chen
Rok vydání:	2018
Předmět:	Reaction conditions 010405 organic chemistry Organic Chemistry Aromatization 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound Cascade reaction chemistry Functional group Pyridine Michael reaction Blaise reaction
Zdroj:	Synlett. 29:959-963
ISSN:	1437-2096 0936-5214
Popis:	This work discloses a novel and efficient protocol for the construction of functionalized chromeno[3,4-c]pyridine derivatives from the Blaise reaction intermediates and 3-cyanocoumarins through a CuCl2-catalyzed sequential Michael addition/intramolecular cyclization/oxidative aromatization reaction. This new method shows the advantages of mild reaction conditions, easy workup, nonchromatographic purification technique, good functional group tolerance, and moderate to good yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::97895ad809df82a1fa26ac3b93f17dd4 https://doi.org/10.1055/s-0036-1591535 Zobrazit plný text záznamu