Direct bromination or hydroxylation at C-11 in vincadifformine and tabersonine derivatives in superacids
Autor: | J.‐C. Jacquesy, Christian Berrier, M. P. Jouannetaud, Y. Vidal |
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Rok vydání: | 1990 |
Předmět: | |
Zdroj: | Tetrahedron. 46:827-832 |
ISSN: | 0040-4020 |
Popis: | In HF-SbF5, vincadifformine 1b reacts with H2O2 to yield a mixture (60%) of hydroxyderivatives 1c and 1d. 2,16-Dihydrovincadifformine 2a is more selectively hydroxylated at C-11 to give 2b (40%); in a similar reaction, 2d yields 2e (37%). Reaction of 2a with Br2 in HF-SbF5 gives regioselectively compound 2c (80%). |
Databáze: | OpenAIRE |
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