Direct bromination or hydroxylation at C-11 in vincadifformine and tabersonine derivatives in superacids

Autor:	J.‐C. Jacquesy, Christian Berrier, M. P. Jouannetaud, Y. Vidal
Rok vydání:	1990
Předmět:	Hydroxylation chemistry.chemical_compound chemistry Vincadifformine Yield (chemistry) Organic Chemistry Drug Discovery Tabersonine Organic chemistry Regioselectivity Halogenation Biochemistry
Zdroj:	Tetrahedron. 46:827-832
ISSN:	0040-4020
Popis:	In HF-SbF5, vincadifformine 1b reacts with H2O2 to yield a mixture (60%) of hydroxyderivatives 1c and 1d. 2,16-Dihydrovincadifformine 2a is more selectively hydroxylated at C-11 to give 2b (40%); in a similar reaction, 2d yields 2e (37%). Reaction of 2a with Br2 in HF-SbF5 gives regioselectively compound 2c (80%).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::97761cb409b82aa937d459be22cc369b https://doi.org/10.1016/s0040-4020(01)81365-x Zobrazit plný text záznamu