Contribution ofin vivo proliferation/differentiation studies toward the development of a combined functional and morphologic system of classification of neoplastic diseases
| Autor: | N. Yousuf, S. A. J. Bokhari, Harvey D. Preisler, Seema A. Khan, Beatrice C. Lampkin, Margaret Masterson, Azra Raza, G A Yanik, A. Mehdi, C. Mazewski |
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| Rok vydání: | 1992 |
| Předmět: |
Cancer Research
Chemotherapy Pathology medicine.medical_specialty medicine.diagnostic_test business.industry medicine.medical_treatment Myeloid leukemia Cell cycle medicine.disease chemistry.chemical_compound Leukemia Oncology chemistry In vivo hemic and lymphatic diseases Biopsy medicine Cancer research Thymidine business Bromodeoxyuridine |
| Zdroj: | Cancer. 69:1557-1566 |
| ISSN: | 1097-0142 0008-543X |
| DOI: | 10.1002/1097-0142(19920315)69:6+<1557::aid-cncr2820691309>3.0.co;2-5 |
| Popis: | Proliferation kinetics of both leukemia and a variety of solid tumors have been assessed after in vivo infusions of the thymidine analogues, iododeoxyuridine (IUdR) and bromodeoxyuridine (BrdU). In acute myeloid leukemia (AML), these data indicate that the pretherapy cell cycle time (Tc) of myeloblasts is a prognostic indicator for remission duration since patients with slowly cycling myeloblasts had more durable remissions. The presence of in vivo differentiation detected from the day 7 biopsy after chemotherapy was also of favorable prognosis as these individuals had statistically significant improvement in their remission duration |
| Databáze: | OpenAIRE |
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