Inhibitory effect of salvinorin A, from Salvia divinorum , on ileitis-induced hypermotility: cross-talk between κ-opioid and cannabinoid CB1 receptors
| Autor: | Pietro Marini, K Huben, Francesca Borrelli, Maria Grazia Cascio, V. Di Marzo, A. A. Izzo, Gabriella Aviello, R Capasso, Francesco Capasso, Barbara Romano, Jordan K. Zjawiony |
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| Rok vydání: | 2008 |
| Předmět: |
Pharmacology
medicine.medical_specialty Cannabinoid receptor biology medicine.drug_class Salvinorin medicine.medical_treatment digestive oral and skin physiology biology.organism_classification Endocannabinoid system κ-opioid receptor Salvinorin A chemistry.chemical_compound Endocrinology chemistry Opioid receptor Internal medicine Salvia divinorum medicine Cannabinoid |
| Zdroj: | British Journal of Pharmacology. 155:681-689 |
| ISSN: | 0007-1188 |
| DOI: | 10.1038/bjp.2008.294 |
| Popis: | Background and purpose: Salvinorin A, the active component of the hallucinogenic herb Salvia divinorum, inhibits intestinal motility through activation of κ-opioid receptors (KORs). However, this compound may have target(s) other than the KORs in the inflamed gut. Because intestinal inflammation upregulates cannabinoid receptors and endogenous cannabinoids, in the present study we investigated the possible involvement of the endogenous cannabinoid system in salvinorin A-induced delay in motility in the inflamed gut. |
| Databáze: | OpenAIRE |
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