ATP-triggered drug release system based on ZIF-90 loaded porous poly(lactic-co-glycolic acid) microspheres
| Autor: | Jin Xu, Wenyu Zhu, Jing Wang, Fengyan Fang, Junqiao Wang, Aohua Cheng, Ziang Gao, Shiyun Ai, Wenli Ding, Yanhui Wei, Chenxi Yu, Zhaozhan He, Ao Huang, Yixiang Wang |
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| Rok vydání: | 2021 |
| Předmět: |
Chemistry
technology industry and agriculture 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Microsphere chemistry.chemical_compound PLGA Colloid and Surface Chemistry Förster resonance energy transfer Chemical engineering Drug delivery Drug release medicine Doxorubicin 0210 nano-technology Porosity Glycolic acid medicine.drug |
| Zdroj: | Colloids and Surfaces A: Physicochemical and Engineering Aspects. 615:126255 |
| ISSN: | 0927-7757 |
| DOI: | 10.1016/j.colsurfa.2021.126255 |
| Popis: | Poly(lactic-co-glycolic acid) (PLGA) based microparticles have been widely applied in drug delivery system, but pristine PLGA particles suffers from low efficiency in release and non-targeted effect for drug delivery system. Inspired by cancer cells environment, we have fabricated an ATP-triggered delivery system based on porous PLGA microspheres covering drug-loaded ZIF-90. The system contains controlled doxorubicin releasing because ZIF-90 nanocrystals are easily collapsed under exposing to high-concentration ATP environment. In addition, ZIF-90@PLGA microparticles also perform low toxicity and 2.37 % hemolysis, and improved fluorescence intensity of doxorubicin by loading riboflavin sodium phosphate benefited from their partial Forster resonance energy transfer. This novel ATP-triggered drug delivery system based on porous PLGA particles could be widely utilized to design effective drug release biomaterials for gastric and lung cancer. |
| Databáze: | OpenAIRE |
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