Effects of [(1-phenyl-5-formyl-1H-imidazol-4-yl)thio]acetic Acid on the Antioxidant Status of the Liver and Kidney in Rats with Tetrachloromethane Poisoning
| Autor: | V. A. Chornous, A. A. Palamar, M. V. Vovk, I. N. Yaremii, A. N. Grozav |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
Toxic hepatitis Antioxidant 010405 organic chemistry Liver and kidney medicine.medical_treatment Thio Oxidative phosphorylation 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry Acetic acid chemistry.chemical_compound Biochemistry chemistry Lipid oxidation Drug Discovery medicine medicine.symptom Homeostasis |
| Zdroj: | Pharmaceutical Chemistry Journal. 54:1101-1105 |
| ISSN: | 1573-9031 0091-150X |
| DOI: | 10.1007/s11094-021-02328-w |
| Popis: | The effects of [(1-phenyl-5-formyl-1H-imidazol-4-yl)thio]acetic acid on oxidant-antioxidant homeostasis in rats with tetrachloromethane poisoning were studied. This compound was found to normalize most parameters of the oxidant-antioxidant balance in the liver and kidneys of animals with toxic hepatitis. These results point to the ability of compounds of this type to suppress free-radical lipid oxidation and oxidative protein modification processes and to activate the antioxidant protection system in animal tissues. |
| Databáze: | OpenAIRE |
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