Stereospecific ligands and their complexes. IV: Synthesis, characterization and cytotoxicity of novel platinum(IV) complexes with ethylenediamine-N,N′-di-S,S-2-propanoate and halogenido ligands: Crystal structure of s-cis-[Pt(S,S-eddp)Cl2]·4H2O and uns-cis-[Pt(S,S-eddp)Br2]
| Autor: | Tibor J. Sabo, Gordana Vasić, Verica V. Glodjović, Vesna M. Djinović, Slobodanka Stanković, Srećko R. Trifunović, Vladimir Trajkovic, Olivera R. Klisurić |
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| Rok vydání: | 2010 |
| Předmět: |
010405 organic chemistry
Stereochemistry Potassium In vitro cytotoxicity chemistry.chemical_element Ethylenediamine Crystal structure 010402 general chemistry 01 natural sciences 3. Good health 0104 chemical sciences Inorganic Chemistry chemistry.chemical_compound Stereospecificity chemistry Materials Chemistry Direct reaction Physical and Theoretical Chemistry Cytotoxicity Platinum |
| Zdroj: | Polyhedron. 29:1933-1938 |
| ISSN: | 0277-5387 |
| DOI: | 10.1016/j.poly.2010.03.004 |
| Popis: | The syntheses of two novel platinum(IV) complexes of formula [PtX2(S,S-eddp)]·nH2O (S,S-eddp = ethylenediamine-N,N′-di-S,S-2-propanoate ion, X = chlorido (1) or bromido (2), n = 4, 0) are reported. The complexes have been obtained by direct reaction of corresponding potassium hexahalogenidoplatinate(IV) with neutralized ethylenediamine-N,N′-di-S,S-2-propanoic acid (H2-S,S-eddp). The complexes were characterized by elemental analysis, infrared, 1H and 13C NMR spectroscopy. The spectroscopically predicted geometrical configurations of the obtained complexes were confirmed by X-ray analyses of the crystal structures of the s-cis-[Pt(S,S-eddp)Cl2]·4H2O and uns-cis-[Pt(S,S-eddp)Br2]. These complexes displayed significantly lower in vitro cytotoxicity in comparison to cisplatin. |
| Databáze: | OpenAIRE |
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