Prospects for a small molecule able to induce somatic growth through the growth hormone receptor
| Autor: | Changmin Chen, Michael J. Waters, S. W. Rowlinson, Becky L. Conway-Campbell, Jennifer E. Rowland, Stuart N. Behncken |
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| Rok vydání: | 1999 |
| Předmět: |
Thyroid hormone receptor
Growth-hormone-releasing hormone receptor Chemistry Bioengineering Biochemistry Molecular biology Analytical Chemistry Cell biology Growth factor receptor Thyrotropin-releasing hormone receptor Interleukin-21 receptor Drug Discovery Molecular Medicine Estrogen-related receptor gamma Insulin-like growth factor 1 receptor Common gamma chain |
| Zdroj: | Letters in Peptide Science. 6:353-357 |
| ISSN: | 1573-3904 0929-5666 |
| DOI: | 10.1007/bf02443432 |
| Popis: | This article reviews the prospects for a small-molecule agonist of the growth hormone receptor in the light of current successes in identifying small agonist molecules for other homomeric class 1 cytokine receptors. A variety of mutagenic analyses on both hormone and receptor, studies with monoclonal antibody agonists of the GH receptor, and the use of a constitutively dimerized GH receptor chimera which displays constitutive activity lead us to believe that such a development is possible. However, it is likely that a precise alignment of the lower cytokine receptor homology domains will be necessary in order to facilitate cross-activation of cytoplasmic Janus kinases bound to Box 1. |
| Databáze: | OpenAIRE |
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