Einfluß von Alkohol auf die Hämodynamik der Pfortader bei nutritiv-toxischer Leberzirrhose

Autor:	C.-P. Klein, J.-F. Kalk, D. Müting, C. G. Klein
Rok vydání:	2008
Předmět:	medicine.medical_specialty Cirrhosis business.industry Portal vein Hemodynamics Alcohol abuse Alcohol General Medicine medicine.disease Gastroenterology chemistry.chemical_compound chemistry Internal medicine medicine business Prospective cohort study Varices Alcohol Abstinence
Zdroj:	DMW - Deutsche Medizinische Wochenschrift. 118:89-93
ISSN:	1439-4413 0012-0472
DOI:	10.1055/s-2008-1059304
Popis:	The influence of alcohol on portal vein haemodynamics was assessed prospectively in 30 patients (20 men, 10 women; mean age 54.3 [34-70] years) with nutritional-toxic cirrhosis of the liver (Child-Pugh stages A-C) and portal vein hypertension. During the period of observation hepatic vein occlusion pressure as an indirect measure of portal vein pressure was repeatedly determined. In addition, the size of oesophageal varices and the Child-Pugh stage were monitored. After complete alcohol abstinence of one year, portal vein pressure fell from 23.11 to 12.43 mm Hg (-46%, P < 0.001), the Child-Pugh score from 8.08 to 7.2 (-10.9%, not significant), and the size of oesophageal varices was reduced from grade 1.33 to grade 0.79 (-40%, P < 0.02). On resuming alcohol abuse, portal vein pressure increased by an average of 10 mm Hg (+60%, P < 0.001) to its previous level of 25 mm Hg. The portal vein pressure has thus proved to be a sensitive gauge of alcohol abstinence or abuse. Lasting, absolute alcohol abstinence is essential in nutritional-toxic liver cirrhosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::974d7c8ca87c6d80230868893913288b https://doi.org/10.1055/s-2008-1059304 Zobrazit plný text záznamu