| Autor: |
Hideyuki Higuchi, H Wada, Masuyuki Kanno, Y Adachi, Tetsuo Satoh |
| Rok vydání: |
2001 |
| Předmět: |
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| Zdroj: |
Acta Anaesthesiologica Scandinavica. 45:1226-1229 |
| ISSN: |
0001-5172 |
| DOI: |
10.1034/j.1399-6576.2001.451009.x |
| Popis: |
Background: We evaluated the effect of low-flow sevoflurane anaesthesia, in which compound A is generated, and isoflurane anaesthesia, in which compound A is not generated (n=13 in each group), on hepatocellular integrity using a glutathione S-transferase (GST). a GST is a more sensitive and specific marker of hepatocellular damage than is aminotransferase activity and correlates better with hepatic histology. Methods: Sevoflurane or isoflurane were delivered without nitrous oxide with a fresh gas flow of 1 l/min. Concentrations of compound A in the circuit were measured hourly, and plasma a GST concentrations were measured perioperatively. Results: Mean duration of anaesthesia was 338±92 min in the sevoflurane group and 320±63 min in the isoflurane group. Mean compound A concentration in the sevoflurane group was 28.6±9.0 ppm. There was no significant difference in a GST concentrations between the sevoflurane and isoflurane groups during or after anaesthesia. Conclusion: These results indicate that low-flow sevoflurane and isoflurane anaesthesia have the same effect on hepatic function, as assessed by plasma a GST concentrations. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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