Synthesis and Antitumor Activity of Novel Thienopyrimidine Derivatives Containing Thiosemicarbazide Moiety

Autor:	Yara El-Dash, Samir B. Salib, Omneya M. Khalil, Mona M. Kamel
Rok vydání:	2016
Předmět:	Antitumor activity Pyrimidine 010405 organic chemistry Stereochemistry Human cell 01 natural sciences Combinatorial chemistry In vitro 0104 chemical sciences 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry 030220 oncology & carcinogenesis Moiety
Zdroj:	OALib. :1-7
ISSN:	2333-9705 2333-9721
DOI:	10.4236/oalib.1102876
Popis:	The present study focused on synthesizing a series of novel derivatives of 4-aryl-1-[2-(3-benzyl-4-oxo(3H)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-ylsulphanyl) acetyl] thiosemicarbazide 5a-d and evaluating their antitumor activity. The structure of the synthesized compounds has been elucidated on the basis of elemental analyses and spectroscopic methods (IR, 1H-NMR, 13C-NMR and MS). The in vitro cytotoxic activity of the synthesized derivatives was evaluated against two human cell lines: prostate cancer (PC-3) and colon cancer (HCT-116).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::97432621d7916c38275985134f583640 https://doi.org/10.4236/oalib.1102876 Zobrazit plný text záznamu