Enantioselectively catalyzed intramolecular cyclopropanations of unsaturated diazo carbonyl compounds

Autor:	Robert T. Hendricks, Michael J. Luzzio, Howard P. Ng, William G. Dauben
Rok vydání:	1990
Předmět:	chemistry.chemical_classification Ketone Intramolecular reaction Bicyclic molecule Cyclopropanation Organic Chemistry Enantioselective synthesis Biochemistry Catalysis chemistry.chemical_compound chemistry Intramolecular force Drug Discovery Organic chemistry Diazo
Zdroj:	Tetrahedron Letters. 31:6969-6972
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)97218-6
Popis:	A series of unsaturated α-diazo carbonyl compounds underwent enantioselective intramolecular cyclopropanation (ee = 4–77%) when treated with an enantiomerically pure chiral copper catalyst. The nature of the diazo substrate was critical: α-diazo ketones gave the best enantioselectivities whereas α-diazo β-keto ester systems showed diminished enantioselectivities.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::97308893d65b6f744a4abf3970a7a83a https://doi.org/10.1016/s0040-4039(00)97218-6 Zobrazit plný text záznamu