IFNA-AS1 regulates CD4+ T cell activation in myasthenia gravis though HLA-DRB1

Autor:	Huan Yang, Mengchuan Luo, Xiaofang Liu, Yuanyuan Xue, Liqun Xu, Zhibin Li, Yu Liu, Yue-Bei Luo, Bo Hu, Huanyu Meng, Zhaohui Luo, Chang Liu, Yi Li
Rok vydání:	2017
Předmět:	0301 basic medicine CD40 Cd4 t cell biology T cell Immunology medicine.disease Myasthenia gravis Pathogenesis 03 medical and health sciences 030104 developmental biology Immune system medicine.anatomical_structure biology.protein medicine Immunology and Allergy HLA-DRB1 Transcription factor
Zdroj:	Clinical Immunology. 183:121-131
ISSN:	1521-6616
DOI:	10.1016/j.clim.2017.08.008
Popis:	Abnormal CD4+T cell activation is known to play roles in the pathogenesis of myasthenia gravis (MG). However, little is known about the mechanisms underlying the roles of lncRNAs in regulating CD4+ T cell. In this study, we discovered that the lncRNA IFNG-AS1 is abnormally expressed in MG patients associated with quantitative myasthenia gravis (QMG) and the positive anti-AchR Ab levels patients. IFNG-AS1 influenced Th1/Treg cell proliferation and regulated the expression levels of their transcription factors in an experimental autoimmune myasthenia gravis (EAMG)model. IFNG-AS1 could reduce the expression of HLA-DRB and HLA-DOB and they had a negative correlation in MG. Furthermore IFNG-AS1 influenced the expression levels of CD40L and CD4+ T cells activation in MG patient partly depend on effecting the HLA-DRB1 expression. It suggests that IFNG-AS1 may be involved in CD4+T cell-mediated immune responses in MG.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::972ad9386f03a8dace03e487fbe3f660 https://doi.org/10.1016/j.clim.2017.08.008 Zobrazit plný text záznamu Full Text from ScienceDirect