Decreased Susceptibility ofStreptococcus pneumoniaeto Fluoroquinolones in Canada
| Autor: | J.C.S. De Azavedo, D K Chen, Don E. Low, Allison McGeer |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
education.field_of_study
Respiratory tract infections Gemifloxacin business.industry medicine.drug_class Population Antibiotics General Medicine medicine.disease_cause Microbiology Ciprofloxacin Minimum inhibitory concentration Streptococcus pneumoniae medicine education business medicine.drug Antibacterial agent |
| Zdroj: | New England Journal of Medicine. 341:233-239 |
| ISSN: | 1533-4406 0028-4793 |
| Popis: | Background Fluoroquinolones are now recommended for the treatment of respiratory tract infections due to Streptococcus pneumoniae, particularly when the isolates are resistant to β-lactam antibiotics. Although pneumococci with reduced susceptibility to fluoroquinolones have been identified, their prevalence has not been determined in a defined population. Methods We performed susceptibility testing on 7551 isolates of S. pneumoniae obtained from surveillance in Canada in 1988 and from 1993 to 1998. Pneumococci with reduced susceptibility to fluoroquinolones (defined as a minimal inhibitory concentration of ciprofloxacin of at least 4 μg per milliliter) were further characterized. We also examined antibiotic prescriptions dispensed in Canadian retail pharmacies. Results Between 1988 and 1997, fluoroquinolone prescriptions increased from 0.8 to 5.5 per 100 persons per year. The prevalence of pneumococci with reduced susceptibility to fluoroquinolones increased from 0 percent in 1993 to 1.7 percent in 1997 a... |
| Databáze: | OpenAIRE |
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