Tissue Distribution of Gentamicin in Lambs: Effect of Postnatal Age and Acute Hypoxemia

Autor:	Douglas N Weismann, O. J. McWeeny, James E. Herrig
Rok vydání:	1982
Předmět:	medicine.medical_specialty business.industry Serum concentration Hypoxemia Postnatal age Endocrinology Internal medicine Anesthesia medicine Pharmacology (medical) Gentamicin Tissue distribution General Pharmacology Toxicology and Pharmaceutics medicine.symptom business medicine.drug
Zdroj:	Developmental Pharmacology and Therapeutics. 5:194-206
ISSN:	2504-2505 0379-8305
DOI:	10.1159/000480996
Popis:	Gentamicin tissue distribution and uptake were studied in chronically catheterized lambs in relation to their possible role in postnatal age- and hypoxemia-related effects on serum gentamicin concentration. Gentamicin serum concentration (SGent) was proportional to dose and was paralleled by gentamicin delivery to specific organ tissues (DGent) and tissue gentamicin content (TGent). SGent per dose was higher in older lambs (2-5 weeks of age) and in hypoxemic (pO2 36 +/- 7 Torr) lambs. DGent to liver, heart and adrenal tissues per unit dose was increased in response to hypoxemia. TGent paralleled SGent under these conditions. Hypoxemia- and age-related effects on SGent were not explained by differences in TGent in these lambs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9719cc671d5b4169f777e4a5e15fd061 https://doi.org/10.1159/000480996 Zobrazit plný text záznamu