Efficacity of a sequential treatment by anti-CD 20 monoclonal antibody and belimumab in type II cryoglobulinaemia associated with primary Sjögren syndrome refractory to rituximab alone
| Autor: | Gaetane Nocturne, Xavier Mariette, Kevin Chevalier, Rakiba Belkhir, Raphaèle Seror |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Immunology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine stomatognathic system Rheumatology immune system diseases hemic and lymphatic diseases Immunology and Allergy Medicine BAFF receptor B-cell activating factor 030203 arthritis & rheumatology business.industry medicine.disease Belimumab Lymphoma stomatognathic diseases 030104 developmental biology Monoclonal Rituximab business Vasculitis Systemic vasculitis medicine.drug |
| Zdroj: | Annals of the Rheumatic Diseases. 79:1257-1259 |
| ISSN: | 1468-2060 0003-4967 |
| Popis: | Primary Sjogren syndrome (pSS) may be complicated by type II cryoglobulinaemia in approximately 5%–20% of patients. pSS is actually the first aetiology of type II cryoglobulinaemia,1 the latter being associated with development of vasculitis, extraglandular involvement, increased risk of B-cell lymphoma and decrease in survival. Rituximab, a monoclonal anti-CD20 antibody, is frequently used in the treatment of cryoglobulinaemia. B-cell activating factor (BAFF), also known as B-lymphocyte stimulator, plays a key role in the survival and activation of B cells. An elevation in BAFF levels occurs after B-cell depletion induced by rituximab.2 It is the consequence of a decrease in B cells that are the most important reservoir of cells expressing the BAFF receptor and of an upregulation of BAFF mRNA.3 The association of belimumab with rituximab could be synergistic and is currently evaluated in pSS and systemic lupus erythematosus.4 We report three cases of patients with refractory cryoglobulinaemic vasculitis complicating pSS successfully treated by the combination of an anti-CD20 therapy followed by belimumab (table 1, … |
| Databáze: | OpenAIRE |
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