The Myth of Optimality in Clinical Neuroscience
| Autor: | Lauren M. Patrick, Avram J. Holmes |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
education.field_of_study Ideal (set theory) Clinical neuroscience Cognitive Neuroscience media_common.quotation_subject Population Experimental and Cognitive Psychology Human behavior 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Neuropsychology and Physiological Psychology Variation (linguistics) Expression (architecture) Isolation (psychology) education Psychology 030217 neurology & neurosurgery Cognitive psychology Diversity (politics) media_common |
| Zdroj: | Trends in Cognitive Sciences. 22:241-257 |
| ISSN: | 1364-6613 |
| DOI: | 10.1016/j.tics.2017.12.006 |
| Popis: | Clear evidence supports a dimensional view of psychiatric illness. Within this framework the expression of disorder-relevant phenotypes is often interpreted as a breakdown or departure from normal brain function. Conversely, health is reified, conceptualized as possessing a single ideal state. We challenge this concept here, arguing that there is no universally optimal profile of brain functioning. The evolutionary forces that shape our species select for a staggering diversity of human behaviors. To support our position we highlight pervasive population-level variability within large-scale functional networks and discrete circuits. We propose that, instead of examining behaviors in isolation, psychiatric illnesses can be best understood through the study of domains of functioning and associated multivariate patterns of variation across distributed brain systems. |
| Databáze: | OpenAIRE |
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