Abstract 441: Cerebral Vasospasm Depends On Rac-1 Mediated Oxidative Stress

Autor:	Carmine Vecchione, Alessandro Landolfi, Alba Di Pardo, Umberto Bettarini, Giuseppe Lembo
Rok vydání:	2007
Předmět:	Physiology (medical) Cardiology and Cardiovascular Medicine
Zdroj:	Circulation. 116
ISSN:	1524-4539 0009-7322
DOI:	10.1161/circ.116.suppl_16.ii_73-b
Popis:	Subarachnoid hemorrhage is one of the most common events related to hypertensive crisis. The cerebral vasospasm is the complication of subarachnoid hemorrhage that causes more frequently death. Experimental evidences describe a direct relationship between hemolysed blood and vasospasm. Understand the molecular basis of vasospasm could help to reduce the mortality in patients with cerebrovascular damage. To clarify this aim, carotid and basilary arteries of rats were mounted on pressure myography and perfused at 100 mmHg. The vessels were placed in intracerebral fluid and entire (eb) or hemolysed blood (hb) was added. Our results showed that the eb did not modify the diameter of the vessel. Meanwhile, hb caused a clear vasoconstriction (max vasoconstriction: 10±1 vs 430±15, p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::970af524e9f51a93a354c41cdf4de3f3 https://doi.org/10.1161/circ.116.suppl_16.ii_73-b Zobrazit plný text záznamu