Treatment of High-Risk Peripheral T-Cell Lymphomas other than Anaplastic Large-Cell Lymphoma with a Dose-Intensified CHOP Regimen Followed by High-Dose Chemotherapy
| Autor: | Shingo Aikawa, Kazuhiro Takei, Takeyoshi Ito, Yoshihiro Hatta, Tetsuo Yamazaki, Jin Takeuchi, Umihiko Sawada, Minoru Saiki, Hikaru Ishizuka, Kumi Uenogawa, Yoshimasa Kura |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Oncology
medicine.medical_specialty Angioimmunoblastic T-cell lymphoma Hepatosplenic T-cell lymphoma business.industry Hematology General Medicine medicine.disease Lymphoma Regimen International Prognostic Index immune system diseases Subcutaneous Panniculitis-Like T-Cell Lymphoma hemic and lymphatic diseases Internal medicine medicine T-cell lymphoma business Anaplastic large-cell lymphoma |
| Zdroj: | Acta Haematologica. 116:90-95 |
| ISSN: | 1421-9662 0001-5792 |
| DOI: | 10.1159/000093637 |
| Popis: | We investigated the efficacy of a dose-intensified double-CHOP regimen followed by high-dose chemotherapy with or without peripheral blood stem cell transplantation (PBSCT) in 11 patients with four types of peripheral T-cell lymphoma (PTCL). Three of the 4 patients with unspecified PTCL (PTCLu) achieved complete response (CR); 1 patient relapsed and 1 died of secondary leukemia after consolidation therapy. All angioimmunoblastic T-cell lymphoma (AILT) and subcutaneous panniculitis-like T-cell lymphoma (SPTCL) patients achieved CR; 5 of 6 have remained disease free for more than 3 years. The patient with hepatosplenic lymphoma did not achieve CR even after PBSCT and underwent allogenic bone marrow transplantation (allo-BMT). Thus, our regimen appears to be effective for high-risk AILT and SPTCL. However, allo-BMT should be considered for high-risk of PTCLu and hepatosplenic T-cell lymphoma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|