Clinical and Magnetic Resonance Imaging Predictors of Disability in Primary and Secondary Progressive Multiple Sclerosis
| Autor: | Kingsley Dp, DH Miller, W. I. McDonald, Aj Thompson, N. A. Losseff |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Pediatrics
medicine.medical_specialty medicine.diagnostic_test business.industry Multiple sclerosis Disease progression Follow up studies Magnetic resonance imaging medicine.disease Surgery 03 medical and health sciences 0302 clinical medicine Neurology Predictive value of tests Medicine Secondary progressive multiple sclerosis 030212 general & internal medicine Neurology (clinical) business Secondary progressive 030217 neurology & neurosurgery |
| Zdroj: | Multiple Sclerosis Journal. 1:218-222 |
| ISSN: | 1477-0970 1352-4585 |
| Popis: | The role of magnetic resonance imaging (MRI) in predicting disability in multiple sclerosis (MS) remains unclear. In this study 21 patients with primary and secondary progressive MS were reviewed 5 years following a serial MRI study of 6 months duration. In the secondary progressive group (n=11) there was a significant relationship between the occurrence of enhancing lesions and clinical relapses during the initial 6 months and increase in diability 5 years later. For both groups change in disability over the initial study period was predictive of outcome. These results suggest that the presence and frequency of gadolinium enhancement (a marker of inflammation) and changes in disability over a short period are predictive of future deterioration in progressive patients. |
| Databáze: | OpenAIRE |
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