Nueroplastic Effects of Transcranial Direct Current Stimulation and Expectations in Aging
| Autor: | Rabipour, Sheida, Bolcakan, Emre, LoParco, Sophia, Khayyat, Lina, Duval, Alicia, Rajah, Maria |
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| Rok vydání: | 2022 |
| Předmět: |
non-invasive brain stimulation
neuroimaging Neuroscience and Neurobiology cognitive intervention Cognitive Neuroscience aging fMRI Life Sciences Psychiatry and Psychology expectation effects Other Psychiatry and Psychology tDCS frontal executive networks mild cognitive impairment Medicine and Health Sciences EEG subjective cognitive decline cognitive enhancement working memory training dementia |
| DOI: | 10.17605/osf.io/vdgpk |
| Popis: | Functions such as the ability to remember past personal experiences (episodic memory) and manipulate information in the short term (working memory) are crucial to autonomously performing activities of daily life. Declines in such cognitive functions – an early potential sign of Alzheimer’s disease – commonly occur with increasing age and are accompanied by altered brain activity and connectivity related to episodic and working memory[1-3]. Our previous work shows these signs are detectible in healthy older adults[3]. Applying weak electric currents to frontal scalp regions using transcranial direct current stimulation (tDCS) is a safe, non-invasive method to promote memory-related synaptic plasticity[4] and network connectivity[5, 6] in regions supporting memory and cognition[5, 6]. Stimulating the left dorsolateral prefrontal cortex (DLPFC) during task performance can improve episodic and working memory[7], and has been associated with increased functional connectivity in memory networks[8]. Such stimulation is therefore promising for prevention of cognitive decline[9]. However, studies report inconsistent findings and remain uncertain about the neural networks through which tDCS influences cognition and behaviour. Moreover, our previous work suggests that expectations of outcomes can affect intervention outcomes[10] and may contribute to variability in reported findings via placebo effects. Evaluating outcome expectancy in a multi-session stimulation intervention is therefore crucial[11]. We propose to examine the effects of brain stimulation and expectations on brain activity and cognitive performance in healthy young adults. Understanding the influence of expectation on tDCS effectiveness, brain function, and cognition can help clarify the neural basis of placebo effects and provide more comprehensive knowledge of tDCS mechanisms for memory enhancement. |
| Databáze: | OpenAIRE |
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