Convenient synthesis and cyclization of dimeric abasic PNA

Autor:	J. William Suggs, Daniel C. Cooper
Rok vydání:	2012
Předmět:	chemistry.chemical_classification chemistry.chemical_compound chemistry Peptide nucleic acid Base pair Stereochemistry Dimer Organic Chemistry Drug Discovery Stacking Biochemistry Alkyl
Zdroj:	Tetrahedron Letters. 53:6943-6945
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2012.10.032
Popis:	The synthesis of an abasic PNA-based dimer block has been achieved. An alkyl chain stapling the two base sites conformationally restricts the PNA backbone, and serves as an example of preorganization by direct base site linkage. Other possible examples of this strategy, such as enforced stacking of adjacent intrastrand bases to give base pair step analogs, are put forward.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::96db3da314edcbe2e17dd9304f010c57 https://doi.org/10.1016/j.tetlet.2012.10.032 Zobrazit plný text záznamu Full Text from ScienceDirect