Rapid determination of low levels of water in pressurized pharmaceutical inhalation aerosol products

Autor:	Phyllis E. Zuk, Jo Anne Trotman, Donna M. Caster, Gregory Rullo
Rok vydání:	1991
Předmět:	Pharmacology Coulometry Chromatography Inhalation Chemistry Organic Chemistry Drug Discovery Pharmaceutical Science Water content Dosage form Aerosol
Zdroj:	Drug Development and Industrial Pharmacy. 17:665-679
ISSN:	1520-5762 0363-9045
DOI:	10.3109/03639049109051598
Popis:	A simple, fast and rugged method for the determination of low levels of water in pressurized pharmaceutical inhalation aerosol products is described. The pressurized canister is pierced and the contents are directly transferred into a Karl Fischer unit. The water content is measured by coulometric titration. This method has been applied to two commercial products and two development formulations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::96d8eab04c706f27ff07646ac716b1f4 https://doi.org/10.3109/03639049109051598 Zobrazit plný text záznamu