Biological Activity of1-alpha-hydroxy Vitamin D3in Vitamin D Dependency

Autor:	Mitio Kumagai, Hideo Cho, Nobutake Matsuo, Yutaka Tsuchiya, Kohji Tsubouchi
Rok vydání:	1979
Předmět:	Vitamin medicine.medical_specialty Chemistry General Engineering chemistry.chemical_element Alpha (ethology) Biological activity Calcium Normal limit chemistry.chemical_compound Endocrinology Urinary excretion Internal medicine medicine Vitamin D and neurology Serum chemistry
Zdroj:	Endocrinologia Japonica. 26:57-63
ISSN:	2185-6370 0013-7219
DOI:	10.1507/endocrj1954.26.supplement_57
Popis:	The biological activity of 1(OH) vitamin D3 was evaluated in 2 cases of vitamin D dependency. For the improvement of serum chemistry and increment of urinary excretion of calcium 1(OH) vitamin D3 was 500--1000 times more active than vitamin D2. The administration of 0.05 microg/kg/day and 0.1 microg/kg/day of 1(OH) vitamin D3 were equally effective to keep the serum chemistry within normal limits. However, urinary excretion of calcium increased to an abnormal height on 0.1 microg/kg/day of 1(OH) vitamin D3. On the other hand, administration of 0.05 microg/kg/day of 1(OH) vitamin D3 kept both serum level and urinary excretion of calcium normal. It is suggested that 0.05 microg/kg/day is close to the optimum requirement of 1(OH) vitamin D3 in vitamin D dependency and this should correspond to the essential requirement of 1(OH) vitamin D3 in man.
Databáze:	OpenAIRE
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