Change over time of bowel habit in irritable bowel syndrome: a prospective, observational, 1-year follow-up study (RITMO study)

Autor:	M. Figueras, Manuel Díaz-Rubio, Mercedes Cucala, Fermín Mearin, V Garrigues, M Roset, X. Badía, AM Caballero, E Domínguez, A Balboa, J. Benavent
Rok vydání:	2007
Předmět:	Change over time medicine.medical_specialty Constipation Hepatology business.industry Bowel habit media_common.quotation_subject digestive oral and skin physiology Gastroenterology 1 year follow up medicine.disease Bristol stool scale Internal medicine medicine Pharmacology (medical) Observational study sense organs Habit medicine.symptom skin and connective tissue diseases business Irritable bowel syndrome media_common
Zdroj:	Alimentary Pharmacology & Therapeutics. 25:323-332
ISSN:	1365-2036 0269-2813
Popis:	Summary Background Evolution of bowel habit in irritable bowel syndrome (IBS) is not well known. Aim To evaluate the change over time of bowel habit in IBS patients followed-up during 1 year. Methods Five hundred and seventeen patients with IBS were prospectively included in an observational study with five evaluations over a 1-year period. Symptoms were recorded daily in diary cards during four 4-week periods along the study. Bristol Stool Scale (BSS) was used to define bowel habit. Results Four-hundred patients completed the study. Rome II showed low–moderate agreement (42%) with BSS to define bowel habit. Frequency of constipation and diarrhoea showed little changes throughout the study. Over 50% of the patients had the same bowel habit when each diary was compared with the next one. A third of patients maintained the same habit throughout the study. Most changes occurred from/to mixed or unsubtyped IBS. Only 14% of cases changed from constipation to diarrhoea or vice versa. This change was associated to female gender (OR: 2.65). Conclusions The frequency of constipation and diarrhoea remains relatively stable over time. Changes in IBS subtypes are common, but changes between constipation and diarrhoea are rare. Alternating IBS is more frequent in women.
Databáze:	OpenAIRE
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