Immunoexpression of Ki-67 and Cyclooxygenase-2 in Odontogenic Keratocyst and Dentigerous Cyst: A Comparative Study
| Autor: | Abd El-Aziz, Enas Alaa Eldin |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty biology business.industry medicine.disease High Mitotic Activity Odontogenic Dentigerous cyst Staining 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Ki-67 medicine biology.protein Epithelial proliferation Cyclooxygenase Keratocyst medicine.symptom business |
| Zdroj: | Egyptian Dental Journal. 65:1367-1375 |
| ISSN: | 2090-2360 |
| DOI: | 10.21608/edj.2019.72561 |
| Popis: | Aims: To evaluate the expression of Cyclooxygenase-2 (COX-2) in odontogenic keratocyst (OKC) and dentigerous cyst and correlate it with Ki-67 expression in these lesions.Material and Methods: This study was carried out on 32 paraffin embedded specimens of dentigerous cyst and OKC. 16 samples obtained from healthy mucosa served as controls. Slides prepared from paraffin-embedded sections were immunohistochemically stained for Ki-67 and COX-2 and immunoreactivity of the two markers was evaluated using index of positivity and staining intensity. Statistical analysis was performed using Mann-Whitney and Spearman’s correlation tests.Results: Ki-67 and COX-2 expression in OKC and dentigerous cyst was found to be significantly higher than those observed in healthy mucosa groups (p < 0.05). The expression of the two markers was significantly higher in OKC than in dentigerous cyst. A positive correlation was found between the two markers in both lesions.Conclusions: Increased expression of Ki-67 and COX- 2 in OKC is an indicator of the high mitotic activity of these lesions compared with dentigerous cyst. COX-2 is implicated in odontogenic epithelial proliferation in OKC and dentigerous cyst. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|