| Autor: |
Tonsing-Carter, Eva, Hernandez, Kyle, Kim, Caroline, Harkless, Ryan, Oh, Alyce, Bowie, Kathleen, West-Szymanski, Diana, Betancourt-Ponce, Mayra, Green, Bradley, Lastra, Ricardo, Gini Fleming, Sarat Chandarlapaty, Conzen, Suzanne |
| Předmět: |
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| Popis: |
Figure S3. GR liganding inhibits MCF-7 mutant ER-driven proliferation and decreases proliferative gene expression. A) Doxycycline induced expression of HA-tagged ER, and GR expression remains stable in all cell lines. B) MCF-7 HA-WT, HA-Y537S, and HA-D538G cells were treated with vehicle (ETOH) and proliferation as evaluated at 6 days of treatment. HA-D538G and HA-Y537S expressing MCF-7 cells show 30–50% increase in cell proliferation, respectively, compared to HA-WT MCF-7 cells. C) Dex, C134 and C335 all significantly inhibited E2-mediated proliferation in both HA-wild type (HA-WT) and HA-D538G MCF-7 cells following 6 days of treatment (*p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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