Computational screening of potential MHC class I restricted cytotoxic T lymphocytes-based common multi-epitopes of major arboviral diseases

Autor:	Rakshanda Sajeed, Kimmi Sarmah, Biswajyoti Borkakoty, Kishore Sarma, Dipankar Biswas
Rok vydání:	2020
Předmět:	0301 basic medicine 03 medical and health sciences 030104 developmental biology 0302 clinical medicine biology viruses Virology MHC class I Immunology biology.protein Cytotoxic T cell 030212 general & internal medicine Epitope
Zdroj:	Future Virology. 15:497-505
ISSN:	1746-0808 1746-0794
DOI:	10.2217/fvl-2019-0160
Popis:	Aim: Arboviral diseases are a health hazard and Flavivirus and Alphavirus infections are the most common in humans. This study focuses on immunoinformatic approaches to identify potential MHC class I restricted epitopes common for some selected arboviral diseases. Materials & methods: T-cell epitope prediction tool of Immune Epitope Database was employed to identify putative epitopes from the polyproteins of the selected viruses. Further, population coverage, conservancy, antigenic properties and docking analyses were performed to identify potential common epitopes for the selected viruses. Results: Eight common epitopes were screened for the selected viruses based on their population coverage, conservancy, antigenic properties and binding affinity. Conclusion: Considering the in silico potency, identified epitopes may further be subjected for candidate vaccine development against these arboviruses.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::96b42971bfa2920316cde0f26df49677 https://doi.org/10.2217/fvl-2019-0160 Zobrazit plný text záznamu