Synthesis of deuterium-labeled zaleplon-d5 as an internal standard

Autor:	Chinpiao Chen, Ajam C. Shaikh
Rok vydání:	2008
Předmět:	medicine.drug_class Chemistry Drug abuser education Organic Chemistry Biochemistry Combinatorial chemistry Analytical Chemistry Hypnotic Zaleplon Drug Discovery medicine Organic chemistry Radiology Nuclear Medicine and imaging Deuterium labeled Spectroscopy medicine.drug
Zdroj:	Journal of Labelled Compounds and Radiopharmaceuticals. 51:72-76
ISSN:	1099-1344 0362-4803
DOI:	10.1002/jlcr.1484
Popis:	Zaleplon is licensed for the short-term treatment of insomnia. Excessive usage causes side effects; hence, the drug is controlled. Identifying zaleplon in a drug abuser requires an isotope-labeled internal standard. This work presents a synthesis of stable isotope-labeled internal standard for zaleplon, zaleplon-d5, by a five-step synthetic sequence. Copyright © 2008 John Wiley & Sons, Ltd.
Databáze:	OpenAIRE
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