Initial Urinary Catecholamine Metabolite Concentrations and Prognosis in Neuroblastoma
| Autor: | Kenneth N. F. Shaw, Joyce Baptista, Morris Gutenstein, Walter E. Laug, Stuart E. Siegel, Benjamin H. Landing |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
medicine.medical_specialty
education.field_of_study business.industry Metabolite Urinary system Population Homovanillic acid medicine.disease Norepinephrine chemistry.chemical_compound Endocrinology chemistry Dopamine Internal medicine Neuroblastoma Pediatrics Perinatology and Child Health Medicine business Vanilmandelic Acid education medicine.drug |
| Zdroj: | Pediatrics. 62:77-83 |
| ISSN: | 1098-4275 0031-4005 |
| DOI: | 10.1542/peds.62.1.77 |
| Popis: | Initial urinary catecholamine metabolite and amino acid excretion patterns were examined in 54 children with neuroblastoma. The relationships between prognosis and age at diagnosis, stage of disease, primary site, and histologic grade of tumor were similar in this population to those found in previous studies, but only age and stage were found to be independent prognostic variables. Prognosis in disseminated disease was found to correlate directly with the urinary vanilmandelic acid (VMA)/homovanillic acid (HVA) ratio but not with the absolute levels of HVA. The presence of the dopa metabolite, vanillactic acid, as well as increased amounts of cystathionine and/or low levels of VMA indicated poor prognosis. These results are consistent with the hypothesis that biochemically primitive neuroblastomas deficient in dopamine β-hydroxylase are more virulent than their mature analogues which produce epinephrine, norepinephrmne, and their metabolites. |
| Databáze: | OpenAIRE |
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