Modeling gene‐environment interaction in longitudinal data: Risk for neuroticism due to interaction between maternal care and the Dopamine 4 Receptor gene (DRD4)

Autor:	Craig A. Olsson, George C Patton, Lana J. Williams, Ottar Bjerkeset, Elya E. Moore, Michael Berk, Elizabeth A. Williamson, Paul B. Badcock, Hans M. Nordahl
Rok vydání:	2011
Předmět:	education.field_of_study medicine.medical_specialty Longitudinal study Population Neuroticism Variable number tandem repeat mental disorders medicine Young adult Big Five personality traits education Psychiatry Psychology General Psychology Cohort study Clinical psychology Adolescent health
Zdroj:	Australian Journal of Psychology. 63:18-25
ISSN:	1742-9536 0004-9530
DOI:	10.1111/j.1742-9536.2011.00003.x
Popis:	The purpose of this study was to investigate risk for neuroticism due to the joint action of low maternal care and compromised mesocorticolimbic ‘reward’ system function linked to a variable number tandem repeat (VNTR) in the dopamine 4 receptor gene (DRD4). Data were drawn from the Victorian Adolescent Health Cohort Study, a longitudinal study of the health and well-being of 2,000 young Australians followed from adolescence to young adulthood across 8 waves from 14- to 28-years. Genetic risk was defined by carriage of at least one copy of the 7-repeat allele or derivative alleles 5, 6, and 8 (labeled 7R+). Neuroticism was assessed in adolescence and young adulthood. We observed an approximately fourfold increase in the odds of reporting neurotic symptoms in carriers of the 7R+ disposition who reported low maternal care compared with non-carriers who reported high maternal care. The percentage of risk attributable to mechanisms in which both factors played a role was 35%. Findings are discussed in terms of implications for prevention.
Databáze:	OpenAIRE
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