| Autor: | Rozenko , Lyudmila Ya., Zinkovich , Michail S., Popova , Natal’ya N., Protasova , Tatjana P., Korobeynikova , Elena P., Arapova , Yulia Yu., Vashchenko , Larisa N., Shikhlyarova , Alla I., Ushakova , Natalia D. |
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| Jazyk: | ruština |
| Rok vydání: | 2017 |
| Předmět: | |
| DOI: | 10.23683/0321-3005-2017-4-2-111-118 |
| Popis: | The nervous system is highly sensitive to ionizing radiation, thus it is one of the main dose-limiting structures in radiotherapy. Side effects accompanying brain radiation require new approaches to reduce the negative consequences. The use of xenon appears promis-ing, since a number of studies demonstrated its neuroprotective effects. EEG parameters were studied in 24 patients of both genders aged 50.5±0.9 years with solitary brain metastases that were divided equally into three groups. Group 1 received adjuvant whole brain irradiation (WBI), group 2 - WBI with the additional boost to the bed of resected metastasis, and group 3 - the scheme similar to the previous one plus xenon-oxygen mixture inhalations. The effect of xenon on the parameters of the bioelectric activity of the brain of patients was studied before, during and after radiotherapy. Spectral EEG power of quiet wakefulness with closed eyes in the frequency range of 0.5 - 18.0 Hz was calculated using the Fourier transform. After the treatment course, patients receiving brain radiation and xenon inhalations showed EEG abnormalities only at the site of metastatic lesion and in adjacent areas and, in contrast to the other two groups, did not involve intact cortex areas. Thus, xenon inhalations are an effective way of radiotherapy optimization. Its neuro-protective and possibly radioprotective effect allows reducing the severity of adverse reactions and improving the functional state of the central nervous system and quality of life of patients with brain metastasis. Such an effect could be associated with the positive influence of xenon not only on the cortex but also on the subcortical structures of the brain. |
| Databáze: | OpenAIRE |
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