Взаємозв’язки порушень біохімічного й імунологічного гомеостазу у хворих на ювенільний ревматоїдний артрит з урахуванням тривалості захворювання
| Autor: | I. M. Nelina, J.M. Zajceva, D. A. Kashkalda, N. S. Shevchenko, I.S. Lebec |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
business.industry
Arthritis Physiology Connective tissue medicine.disease Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Immune system medicine.anatomical_structure Connective tissue metabolism General Earth and Planetary Sciences Medicine 030212 general & internal medicine business Pathological 030217 neurology & neurosurgery Juvenile rheumatoid arthritis General Environmental Science Subclinical infection |
| Zdroj: | CHILD`S HEALTH. 13:19-27 |
| ISSN: | 2307-1168 2224-0551 |
| Popis: | Background. Juvenile rheumatoid arthritis (JRA) is a life-long pathological condition. Therefore, the study of the mechanisms of its development, the metabolic systems functioning, the formation of dystrophic changes on the background of the inflammatory process is relevant. The purpose of the work was to study the features of metabolism of connective tissue structures depending on the state of immune homeostasis at the stages of evolution of the JRA in pediatric patients. Material and methods. The peculiarities of the structural composition of the connective tissue components, the content of trace elements, and immunological homeostasis in children with JRA were studied. Three hundred fifty-five clinical observations of JRA taking into account retro- and advanced studies for 2012–2016 were analyzed. The clinical group consisted of 117 arthritis patients aged 2 to 18 years (average 6.0 ± 0.5 years). Results. Investigation of immune status determined the decreased T-common lymphocytes (p |
| Databáze: | OpenAIRE |
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