Aromatasehemmer-assoziierte Arthralgien: klinische Erfahrungen und Therapieempfehlungen
| Autor: | Nicolai Maass, S Zaun, WW Bolten, P. Hadji, C. Jackisch |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty business.industry Incidence (epidemiology) Obstetrics and Gynecology Cancer medicine.disease Breast cancer Intervention (counseling) Internal medicine Joint pain Maternity and Midwifery medicine Physical therapy medicine.symptom Disease management (health) skin and connective tissue diseases business Tamoxifen Patient education medicine.drug |
| Zdroj: | Geburtshilfe und Frauenheilkunde. 68:977-985 |
| ISSN: | 1438-8804 0016-5751 |
| Popis: | OBJECTIVE: It is well documented that aromatase inhibitors (AI) are superior to tamoxifen as an adjuvant endocrine therapy in postmenopausal women with hormone receptor-positive breast cancer. However, compared with tamoxifen, an elevated incidence of arthralgia has been observed during AI treatment. Concerns have been raised that AI-induced arthralgia may dissuade patients from completing their full AI treatment course. Patient education on the possibility of experiencing arthralgia and the effective management of symptoms, if they appear, is important in helping patients adhere to AI treatment schedules and, consequently, in improving breast cancer outcomes. METHODS: In this paper, we discuss the potential mechanisms behind AI-induced arthralgia, review the frequency with which arthralgia occurs, and propose an algorithm specifically for the treatment of AI-induced arthralgia. As with joint pain in non-breast cancer patients, a sequential approach to disease management is recommended, involving modifications of the patient's lifestyle in addition to taking a stratified approach to pharmacological intervention with analgesia and anti-inflammatory medication. CONCLUSION: Knowing that joint symptoms can be managed in most patients may encourage patient-physician communication and treatment compliance. A specific treatment algorithm is proposed that may support doctors and patients when dealing with AI-induced arthralgia. |
| Databáze: | OpenAIRE |
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