Role of EDHF in the vasodilatory effect of loop diuretics in guinea-pig mesenteric resistance arteries
| Autor: | Catherine Bappel-Gozalbes, Jean-Louis Freslon, Fabrice Pourageaud, Roger Marthan |
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| Rok vydání: | 2000 |
| Předmět: |
Pharmacology
Endothelium-derived hyperpolarizing factor medicine.medical_specialty Charybdotoxin Piretanide Vasodilation Hyperpolarization (biology) Iberiotoxin Apamin chemistry.chemical_compound medicine.anatomical_structure Endocrinology chemistry Internal medicine cardiovascular system medicine Mesenteric arteries |
| Zdroj: | British Journal of Pharmacology. 131:1211-1219 |
| ISSN: | 0007-1188 |
| DOI: | 10.1038/sj.bjp.0703693 |
| Popis: | Relaxing effect of loop diuretics, piretanide and furosemide in comparison with acetylcholine (ACh) was investigated in guinea-pig isolated mesenteric resistance arteries. Concentration-response curves to ACh (0.001–10 μM) and diuretics (0.0001–1 μM) were constructed in noradrenaline (10–30 μM)-precontracted arteries incubated either in normal physiological salt solution (PSS) or in 30 mM KCl PSS (K-PSS). In PSS, maximal relaxations (Rmax) and pD2 to ACh were 87±2% and 7.1±0.1 (n=10). L-NG-nitro-arginine methyl ester (L-NAME, 100 μM) reduced Rmax by 20% (P |
| Databáze: | OpenAIRE |
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